Controlled ovarian stimulation using highly purified FSH results in a lower serum oestradiol profile in the follicular phase as compared with HMG
نویسندگان
چکیده
منابع مشابه
Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients.
BACKGROUND Highly purified menotrophin (HP-hMG) has been associated with fewer oocytes retrieved and a higher proportion of top-quality embryos compared with recombinant FSH (rFSH). METHODS A randomized, assessor-blind, multinational trial in 731 women undergoing IVF after stimulation with HP-hMG (MENOPUR) (n = 363) or rFSH (GONAL-F) (n = 368) following a long GnRH agonist protocol was conduc...
متن کاملHighly purified HMG versus recombinant FSH for ovarian stimulation in IVF cycles.
The objective of this study was to compare the live birth rates resulting from ovarian stimulation with highly purified human menopausal gonadotrophin (HP-HMG), which combines FSH and human chorionic gonadotrophin-driven LH activities, or recombinant FSH (rFSH) alone in women undergoing IVF cycles. An integrated analysis was performed of the raw data from two randomized controlled trials that w...
متن کاملHighly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists--a randomized study.
BACKGROUND Highly purified hMG (hp-hMG) has recently shown better cycle outcome than the recombinant FSH (rFSH) when compared in GnRH agonist long protocol cycles. However, they have not yet been compared in GnRH antagonist cycles. METHODS A RCT comparing the ongoing pregnancy rate (primary end-point) in 280 patients undergoing IVF/ICSI after stimulation with hp-hMG or rFSH controlled with a ...
متن کاملFollicular fluid hormone concentrations after ovarian stimulation using gonadotropin preparations with different FSH/LH ratios. I. Comparison of an FSH-dominant and a purified FSH preparation.
OBJECTIVE A small amount of LH is necessary for 17beta-estradiol production in the ovarian follicle. Human menopausal gonadotropin (hMG) contains equal amounts of FSH and LH activity, whereas recombinant FSH is a gonadotropin preparation without LH. The aim of the present randomized study was to investigate whether ovarian stimulation treatment with recombinant FSH or hMG resulted in different ...
متن کاملFollicular Fluid Hormone Concentrations During Controlled Ovarian Hyperstimulation using Gonadotropin Preparations with Different FSH/LH Ratios. . Comparison of an FSH-Dominant and a Purified FSH preparation
Objective—The aim of the present randomized study was to investigate w hether ovarian s tim u lation treatm ent with gonadotropin preparations containing different am ounts of LH activity resulted in variations of steroidal composition of follicular fluid. A different endocrine m ilieu w ith in the follicle m ight influence oocyte quality. Methods—Antral fluid from m ature follicles was collec...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 1996
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/11.3.474